Early Sedation with Dexmedetomidine Reduces Patient Stress

About 103 patients were considered for this study’s final tally. Comparable rates of propofol use and median doses were seen across groups, as was the baseline severity of illness (APACHE II score). More of the usual-care patients received midazolam (57.7% vs. 33.3%; P=0.01) and at a higher dose (median (95% interquartile range) of 0.46 [0.20–0.93] vs. 0.14 [0.08–0.38] mg/kg/day; P<0.01). Adrenaline (0.32 [0.26-0.4] vs. 0.38 [0.31-0.48]), noradrenaline (4.27 [3.12-5.85] vs. 6.2 [4.6-8.5]), adrenocorticotropic hormone (17.1 [15.1-19.5] vs. 18.1 [15.9-20.5]), and cortisol (515 [409-648] vs. 618 [491-776)] plasma levels did not differ between Other biomarkers and physiological indicators were not significantly different. Both age and sepsis were shown to have no impact in sensitivity studies.

Changes in physiological and blood-borne markers linked with the stress response were similar between early sedation with dexmedetomidine as the major sedative agent and standard-of-care sedation in mechanically ventilated critically ill people.

Source: ccforum.biomedcentral.com/articles/10.1186/s13054-022-04237-0

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Early Sedation with Dexmedetomidine Reduces Patient Stress

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